What cancer does AFP detect?

What cancers have high AFP?

High levels of AFP can be a sign of liver cancer or cancer of the ovaries or testicles, as well as noncancerous liver diseases such as cirrhosis and hepatitis. High AFP levels don’t always mean cancer, and normal levels don’t always rule out cancer.

How accurate is AFP test for cancer?

The sensitivity and specificity of AFP >20 ng/mL for the detection of HCC were 70.1% and 89.8%, respectively.

What does AFP blood test show?

An AFP blood test is used to check a developing fetus for risk of birth defects and genetic disorders, such as neural tube defects or Down syndrome.

Are AFP tumor markers accurate?

Optimal cutoff values that provide the best LR+ were 200 ng/ml for AFP, 40 mAU/ml for DCP, and 15% for AFP-L3. Conclusions Diagnostic accuracy of AFP in small HCC was substantially limited. Surveillance including other tumor markers with optimal cutoff value should be conducted to confirm the efficacy of the policy.

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How high can AFP levels go?

Some reports indicate that healthy individuals may have AFP levels of up to 20 ng/mL, and levels above this are considered to indicate the possibility of liver disease [16]. The normal range is given as 0 to 7.22 mg/mL in our laboratory and, in the current case, the AFP level was persistently above this range.

What causes AFP levels to rise?

Outside of pregnancy and birth, liver damage and certain cancers can increase AFP levels significantly. This test measures the level of AFP in your blood. AFP is produced whenever liver cells are regenerating. With chronic liver diseases, such as hepatitis and cirrhosis, AFP may be chronically elevated.

What is a normal AFP level?

An AFP level between 10 ng/mL to 20 ng/mL is normal for adults. An extremely high level of AFP in your blood—greater than 400 ng/mL—could be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin disease, lymphoma, and renal cell carcinoma (kidney cancer).

What can cause a false-positive AFP test?

False-positive results may be because the mother is carrying twins, inaccurate dates, a low birth weight infant, a large placenta or a sample that was contaminated. Abnormal results are also associated with the fact that the baby may be a girl.

Can stress cause tumor markers to rise?

The study, which followed 96 patients with chronic lymphocytic leukemia (CLL), found that those who felt more stress and anxiety about about their condition also had a higher volume of cancer cells in their blood and higher blood levels of markers for advanced disease.

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What happens if an AFP test is positive?

What does it mean if my AFP PLUS test result is screen positive? A positive AFP PLUS test means that you are in a higher likelihood group for having a baby with a neural tube defect or a chromosome abnormality. However, it does not prove by itself that there is anything wrong with the pregnancy.

When should AFP test be done?

The level of AFP in the blood is used in a maternal serum triple or quadruple screening test. Generally done between 15 and 20 weeks, these tests check the levels of three or four substances in a pregnant woman’s blood.

Why is AFP low in Down syndrome?

Causes of this decrease may include the production of an altered AFP molecule with modified turnover or transport properties, or a reduction in the level of AFP synthesis.

What is considered a high tumor marker number?

Normal range: < 2.5 ng/ml. Normal range may vary somewhat depending on the brand of assay used. Levels > 10 ng/ml suggest extensive disease and levels > 20 ng/ml suggest metastatic disease.

How do I lower my AFP?

Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL ( for each).

What is a normal AFP level at 16 weeks?

Before 14 weeks, AFP helps to diagnose neural tube defects. Normal AFP <2.5 Multiples of median (MoM).

Pathophysiology.

Maternal serum level AFP
14 weeks of gestation 25.6 ng/mL (median)
16 weeks of gestation 34.8 ng/mL (median)
18 weeks of gestation 47.3 ng/mL (median)
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