What is diffuse carcinoma in situ?

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Is carcinoma in situ really cancer?

In general, carcinoma in situ is the earliest form of cancer, and is considered stage 0. An example of carcinoma in situ is ductal carcinoma in situ, or DCIS, which is considered an early form of breast cancer and occurs when abnormal cells form a breast’s milk duct.

What does carcinoma in situ of bladder mean?

Carcinoma in situ (also called CIS or Tis) means very early, high grade cancer cells that are only in the innermost layer of the bladder lining. It is a non invasive cancer of the flat urothelial or transitional cells.

What is the treatment for carcinoma in situ?

TREATMENT APPROACH Patients with DCIS undergo local treatment with breast-conserving therapy (BCT) or mastectomy. BCT consists of lumpectomy (also called breast-conserving surgery, wide excision, or partial mastectomy) followed in most cases by adjuvant radiation.

What is the difference between carcinoma in situ and invasive carcinoma?

In situ breast cancer (ductal carcinoma in situ or DCIS) is a cancer that starts in a milk duct and has not grown into the rest of the breast tissue. The term invasive (or infiltrating) breast cancer is used to describe any type of breast cancer that has spread (invaded) into the surrounding breast tissue.

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Is carcinoma in situ of bladder curable?

These cancers can be cured with treatment. During long-term follow-up care, more superficial cancers are often found in the bladder or in other parts of the urinary system. Although these new cancers do need to be treated, they rarely are deeply invasive or life threatening.

What is high-grade urothelial carcinoma?

High-grade tumors have an aggressive appearance under a microscope and are assumed invasive in the kidney or ureter. In the bladder, a thick bladder muscle (called the detrusor) acts as a barrier to confine invasive cancers but in the kidney and ureter, this muscle does not exist.

Does size of bladder tumor matter?

CONCLUSIONS: Larger tumor size (>5 cm) is associated with greater length of stay, reoperation, readmission, and death following TURBT. Patients should be counseled appropriately and likely warrant vigilant observation prior to and following hospital discharge.

How common is carcinoma in situ cervix?

The mean age at diagnosis is 35–37 years,6,7 and the current incidence rate is approximately 6.6 per 100,000 persons, increasing to 11.2 per 100,000 persons at the peak age of 30–39 years. The average interval between a diagnosis of clinically detectable AIS and early invasive cancer is at least 5 years.

Is carcinoma in situ reversible?

Precancer progresses through dysplastic phases to carcinoma in situ and these changes can be documented by aneuploidy in the abnormal cells. Some of all these degrees of dysplasia, including carcinoma in situ, have been shown to be reversible.

Is severe dysplasia the same as carcinoma in situ?

“severe dysplasia” may be used as synonyms for in situ adenocarcinoma and in situ carcinoma. These are now the preferred terms used by pathologists rather than adenocarcinoma/carcinoma in situ.”

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What are the symptoms of carcinoma in situ?

When ductal carcinoma in situ does produce symptoms, the most common include:

  • Breast pain.
  • Bloody discharge from the nipple.
  • A palpable lump in the breast tissue.
  • A red, scaly rash known as Paget’s disease of the breast.

What does in situ mean in medical terms?

(in SY-too) In its original place. For example, in carcinoma in situ, abnormal cells are found only in the place where they first formed.

What causes carcinoma in situ?

It’s not clear what causes DCIS. DCIS forms when genetic mutations occur in the DNA of breast duct cells. The genetic mutations cause the cells to appear abnormal, but the cells don’t yet have the ability to break out of the breast duct.