Best answer: How successful is stem cell transplant for Hodgkin’s lymphoma?

What is the success rate of stem cell transplant with lymphoma?

High-dose chemotherapy and autologous or allogeneic stem cell transplantation has been reported to cure approximately 15% of patients with resistant lymphoma and 20%-30% of patients with Burkitt’s lymphoma still sensitive to treatment with chemotherapy.

How effective is stem cell transplant in Hodgkin’s lymphoma?

Autologous stem cell transplant (ASCT) for patients with relapsed/refractory disease after front-line chemotherapy offers PFS rates of 50% to 60% and 40% to 45% in patients with chemosensitive disease and primary refractory cHL, respectively.

Can Hodgkin’s lymphoma come back after stem cell transplant?

Recurrence of Hodgkin lymphoma (HL) occurs in about 50% of patients after autologous stem cell transplantation (ASCT), usually within the first year, and represents a significant therapeutic challenge. The natural history of recurrent HL in this setting may range from a rapidly progressive to a more indolent course.

Can lymphoma be cured with stem cell transplant?

When might stem cell transplants be used to treat lymphoma? Stem cell transplants are an intensive form of treatment and you have to be well enough to have one. They can be used to treat some types of Hodgkin lymphoma, high-grade non-Hodgkin lymphoma and low-grade non-Hodgkin lymphoma.

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What is the life expectancy after a stem cell transplant?

Overall, the estimated survival of the study cohort was 80.4% (95% CI, 78.1% to 82.6%) at 20 years after transplantation.

Do you need chemo after stem cell transplant?

But with a stem cell transplant, doctors can give high doses of chemo because the patient receives a transplant of blood-forming stem cells to restore the bone marrow afterwards. Stem cell transplants are sometimes used to treat lymphoma patients who are in remission or who have a relapse during or after treatment.

What is the survival rate for Hodgkin’s lymphoma?

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed.

5-year relative survival rates for Hodgkin lymphoma.

SEER Stage 5-Year Relative Survival Rate
All SEER stages combined 87%

How long is chemo before stem cell transplant?

Before the stem cell transplant, a child is usually given about 5 months of intense chemotherapy and sometimes surgery to remove the tumor as well. Some children might get 2 stem cell transplants a few months apart, called tandem stem cell transplants.

Can Hodgkin’s lymphoma be completely cured?

Overall, treatment for Hodgkin lymphoma is highly effective and most people with the condition are eventually cured.

How likely is Hodgkin’s lymphoma returning?

With Hodgkin lymphoma, more than half of recurrences occur within two years of the primary treatment and up to 90% occur before the five-year mark. The occurrence of a relapse after 10 years is rare and after 15 years the risk of developing lymphoma is the same as its risk in the normal population.

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What are the odds of lymphoma returning?

Although the majority of patients with classical Hodgkin lymphoma (cHL) are cured in the modern treatment era, up to 30%1,2 with advanced-stage and 5% to 10%36 with limited-stage disease experience relapse.