What is T1 in bladder cancer?
T1: The tumor has spread to the connective tissue (called the lamina propria) that separates the lining of the bladder from the muscles beneath, but it does not involve the bladder wall muscle. T2: The tumor has spread to the muscle of the bladder wall.
Can low grade bladder cancer be invasive?
Low-grade noninvasive bladder cancer rarely turns into aggressive, invasive, or metastatic disease, but patients are at risk for developing more low-grade cancers throughout their life. This requires long-term checkups, called surveillance, using cystoscopy and urine cytology (see Diagnosis).
Does low grade bladder cancer become high grade?
Bladder cancer can also be described as either low grade or high grade. Low grade bladder cancer means that your cancer is less likely to grow, spread and come back after treatment. High grade means your cancer is more likely to grow spread and come back after treatment.
Are most bladder cancers low grade?
Most bladder tumours are low grade. The cancer cells look very abnormal and grow quickly. They are more likely to spread both into the bladder muscle and outside the bladder. In non-muscle-invasive tumours, the grade may be low or high, while almost all muscle-invasive cancers are high grade.
What is the prognosis for T1 bladder cancer?
T1Hg bladder cancer progresses to muscle-invasive or metastatic disease at a rate of 30% to 50% after 5 years. As a result, some studies advocate initial cystectomy based on the perceived acceptable morbidity and a 5-year disease-specific survival rate of 80% to 90%.
What is the best treatment for T1 bladder cancer?
BCG instillation into bladder is the gold standard for conservative treatment for high-grade T1 disease. The therapeutic effect of BCG in high-grade T1 has already been established by several meta-analysis studies [4,36,37].
What percentage of bladder tumors are low grade?
Approximately 50 % of newly diagnosed cases of bladder cancer are low grade, noninvasive and papillary tumors .
What is low grade cancer in the bladder?
Low-grade bladder cancer.
This type of cancer has cells that are closer in appearance and organization to normal cells (well differentiated). A low-grade tumor usually grows more slowly and is less likely to invade the muscular wall of the bladder than is a high-grade tumor.
Is bladder cancer curable if caught early?
Bladder cancer is usually treatable when caught at an early stage but more challenging to address when found later. Recurrence also poses a risk, even with early-stage tumors, so regular surveillance is essential following treatment or surgery.
Does low grade tumor mean cancer?
Cancer cells that look and organize most like healthy cells and tissue are low grade tumors. Doctors describe these cancers as being well differentiated. Lower grade cancers are typically less aggressive and have a better prognosis.
Do you feel ill with bladder cancer?
Feeling weak or fatigued: You may feel lethargic and extremely tired a lot of the time. Bone pain: If your cancer has spread to the bone, it can cause bone pain or a bone fracture.
Can low grade cancer spread?
Low-grade cancer cells look more like normal cells and tend to grow and spread more slowly than high-grade cancer cells. Cancer grade may be used to help plan treatment and determine prognosis. Low-grade cancers usually have a better prognosis than high-grade cancers and may not need treatment right away.