Do granulosa cell tumors produce testosterone?

What hormone does a granulosa cell tumor make?

Inhibin expressed by granulosa cell tumors suppresses FSH release from the pituitary gland and consequently, estrogen production from the normal ovary.

What do granulosa cell tumors secrete?

Granulosa cell tumors (GCTs) are derived from the cells that surround developing ovarian follicles. GCTs are typically unilateral and solid and secrete estrogen. Pathologists distinguish between two subtypes of GCT based on the cell of origin: 95% are the adult form and 5% the juvenile subtype.

What are the symptoms of granulosa cell Tumour?

The clinical symptoms of GCT are abdominal pain and abnormal vaginal bleeding, and some cases may also present with menorrhagia, irregular menstruation, or amenorrhea in the reproductive age group. GCT is a cancer with long natural history, and recurrence often happens after 5 years of follow-up [1].

Can ovarian tumors cause high testosterone?

A rare type of ovarian tumor can raise testosterone levels, causing women to develop male characteristics. The main treatments: surgery and chemotherapy.

Can a granulosa cell tumor be benign?

These can be non cancerous (benign) or cancerous (malignant). Granulosa cell tumours are the most common type. Treatment depends on several factors including your age, the type of tumour, and how advanced it is (the stage). Most women are diagnosed at an early stage and treatment usually works well.

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What type of tumor is granulosa cell tumor?

Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman’s body.

Are all granulosa cell tumors malignant?

Adult granulosa cell tumor (GCT) is a rare ovarian malignancy accounting for 1-2% of all tumors and 95% of germ cell tumors originating from sex cord-stromal cells. [1,2,3] These have good prognosis in comparison with other epithelial tumors.

Is granulosa cell tumor hereditary?

Adult granulosa cell tumors can occur in familial clusters and could potentially be hereditary. We did not identify an overlapping genetic variant or affected genetic locus that may explain a genetic predisposition for AGCT in the four investigated families.

Is granulosa cell tumor curable?

Answer: Granulosa cell tumor is a slow-growing cancer that starts in the granulosa cells that surround the eggs within the ovary. Diagnosed and treated early, it’s not likely to return.

What is a Brenner tumor?

Brenner tumor of the ovary is a solid, abnormal growth (tumor) on the ovary. Most Brenner tumors are not cancerous (benign). About 5% of Brenner tumors are cancerous (malignant) or have a small chance of spreading beyond its original location (borderline). These tumors most often occur in women after menopause.

What is the function of granulosa cells?

The granulosa cell (GC) is a critical somatic component of the ovary. It is essential for follicle development by supporting the developing oocyte, proliferating and producing sex steroids and disparate growth factors.

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