Does cancer therapy accelerate malignant progression?


What 3 features of cancer cells that allow them to become metastatic?

However in very basic terms, the acquisition of metastasis requires several fundamental steps including (1) loss of cell-cell adhesion, (2) acquisition of motility and (3) the ability to digest through the basement membrane to enter the circulation.

Is a malignant tumor capable of spreading?

A malignant tumor, however, is capable of both invading surrounding normal tissue and spreading throughout the body via the circulatory or lymphatic systems (metastasis). Only malignant tumors are properly referred to as cancers, and it is their ability to invade and metastasize that makes cancer so dangerous.

What is malignant progression?

The change of cells from benign to malignant behavior is called malignant progression or transformation. Malignant progression is characterized by the acquisition of progressive and uncontrolled growth of tumor cells. Malignant tumors have the ability to invade adjacent tissues and spread to distant sites in the body.

What is the life expectancy of someone with metastatic cancer?

A patient with widespread metastasis or with metastasis to the lymph nodes has a life expectancy of less than six weeks. A patient with metastasis to the brain has a more variable life expectancy (one to 16 months) depending on the number and location of lesions and the specifics of treatment.

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What is the difference between a malignant tumor and a metastasis?

Malignant tumors have cells that grow uncontrollably and spread locally and/or to distant sites. Malignant tumors are cancerous (ie, they invade other sites). They spread to distant sites via the bloodstream or the lymphatic system. This spread is called metastasis.

Are malignant tumors capsulated?

Some malignant tumors remain localized and encapsulated, at least for a time; an example is carcinoma in situ in the ovary or breast.

Do malignant tumors have capsules?

Malignant tumours, on the other hand, lack a true capsule and, even when limited to a specific location, invariably can be seen to have infiltrated surrounding tissues. The ability to invade adjacent tissues is a major characteristic that distinguishes malignant tumours from benign tumours.

Are cancers tumors?

What is the difference between a tumor and cancer? Cancer is a disease in which cells, almost anywhere in the body, begin to divide uncontrollably. A tumor is when this uncontrolled growth occurs in solid tissue such as an organ, muscle, or bone.