Can chemotherapy cause low magnesium levels?
Platinum chemotherapy drugs including Cisplatin and Carboplatin, although effective cancer drugs, are also known to cause severe side-effects, one of them being a drastic depletion in the levels of the essential mineral Magnesium in the body, that leads to kidney injury.
Is low magnesium common in cancer patients?
Epidemiological studies identify magnesium deficiency as a risk factor for some types of human cancers. In addition, impaired magnesium homeostasis is reported in cancer patients, and frequently complicates therapy with some anti-cancer drugs.
Does chemo affect magnesium?
There was a statistically significant decrease in magnesium levels from baseline to the lowest magnesium level (mean = 0.68 mmol/l, standard deviation = 0.13) (P < 0.0005). The incidence of hypomagnesaemia (serum magnesium < 0.7 mmol/l) at any point during chemotherapy was 43%.
Why is magnesium important during chemotherapy?
Several studies have demonstrated that magnesium administered during chemotherapy treatment has a protective effect against nephrotoxicity.
What causes low magnesium in the blood?
The causes of magnesium deficiency vary. They range from inadequate dietary intake to loss of magnesium from the body ( 2 ). Health problems associated with magnesium loss include diabetes, poor absorption, chronic diarrhea, celiac disease and hungry bone syndrome.
Why do cancer patients take magnesium?
In regard to cancer, magnesium intake has been associated with the incidence of some cancers and has been studied as a protective agent against chemotherapy-induced nephrotoxicity and neurotoxicity.
What does low magnesium mean in a cancer patient?
Hypomagnesemia, in both acute and chronic forms, is associated with poor clinical outcomes. Chronic hypomagnesemia is implicated in developing insulin resistance, diabetes, more rapid progression of diabetic nephropathy, nephrolithiasis, fracture, and increased risk for cancer (11⇓–13).
What are side effects of low magnesium?
As magnesium deficiency worsens, symptoms may include:
- muscle cramps.
- muscle spasticity.
- personality changes.
- abnormal heart rhythms.
What depletes the body of magnesium?
The use of chemicals, such as fluoride and chlorine, bind to magnesium, making the water supply low in the mineral, as well. Common substances — such as sugar and caffeine — deplete the body’s magnesium levels.
What food is highest in magnesium?
In general rich sources of magnesium are greens, nuts, seeds, dry beans, whole grains, wheat germ, wheat and oat bran. The recommended dietary allowance for magnesium for adult men is 400-420 mg per day. The dietary allowance for adult women is 310-320 mg per day.
How do you fix magnesium?
Treat with magnesium salts when magnesium deficiency is symptomatic or persistently < 1.25 mg/dL (< 0.50 mmol/L). Give oral magnesium salts unless patients have seizures or other severe symptoms, in which case, give 2 to 4 g of magnesium sulfate IV over 5 to 10 minutes.