Frequent question: What is the difference between induction and neoadjuvant chemotherapy?

How is neoadjuvant chemotherapy administered?

Neoadjuvant chemotherapy is administered in cycles, with each cycle consisting of a treatment period followed by a resting phase. Chemotherapy agents are given orally or intravenously in cycles spanning between 3 to 6 months.

What is neoadjuvant chemotherapy?

Neoadjuvant chemotherapy is chemotherapy that a person with cancer receives before their primary course of treatment. The aim is to shrink a cancerous tumor using drugs before moving onto other treatments, such as surgery. Neoadjuvant chemotherapy helps doctors target cancerous growths more easily at a later stage.

When is neoadjuvant chemotherapy used?

Before surgery (neoadjuvant chemotherapy): Neoadjuvant chemo might be given to try to shrink the tumor so it can be removed with less extensive surgery. Because of this, neoadjuvant chemo is often used to treat cancers that are too big to be removed by surgery when first diagnosed (called locally advanced cancers).

How does induction chemotherapy work?

Induction chemotherapy is administered to produce a complete remission in the bone marrow, which is defined as less than 5% “blasts” in the bone marrow sample and a return to normal blood counts.

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Do you lose hair with neoadjuvant chemotherapy?

Most side effects are short-term and subside when treatment is over. Side effects may include: Hair loss. Extreme fatigue.

Is neoadjuvant chemotherapy successful?

In patients with locally advanced breast cancer without inflammatory disease who were breast-conserving therapy candidates after neoadjuvant therapy, the overall 5-year survival is an astounding 96%. In fact, even in the patients with inflammatory breast cancer there is an impressive 67% survival.

What is the main benefit of neoadjuvant therapy?

The advantages of neoadjuvant chemotherapy are 1) overall survival and recurrence-free survival rate are the same as post-operative chemotherapy, 2) serves as an in vivo sensitivity test, 3) increases the rate of breast conserving therapy, 4) facilitates the study of cancer biology.

What is the goal of neoadjuvant chemotherapy?

Neoadjuvant therapy is recommended for most patients with locally advanced disease. The objectives of neoadjuvant therapy are to decrease the tumor burden which may enable more patients to undergo potentially curative surgical resection, and diminish the risk of recurrence.

How many cycles of neoadjuvant chemotherapy are there?

Four large randomized studies comparing neoadjuvant chemotherapy followed by interval debulking surgery with primary debulking surgery examined the use of three to four cycles. (5), (6), (7), (8) However, in real-world practice, centers often treat patients with four cycles or more.

How soon after neoadjuvant chemo do most get surgery?

Conclusion: Our patients showed improved pCR if surgery was performed within 8 weeks, especially for ER+/HER-2+ patients. All patients had better OS and DFS trends if surgery was performed between 4 and 7 weeks after neoadjuvant chemotherapy.

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How many rounds of chemo is normal?

During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.

What is the strongest chemo drug?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.