Frequent question: What is the most common histology of bladder cancer?

What is the most common histological type of bladder cancer?

Pure urothelial carcinoma is the most common histology of bladder cancer, consisting of about 75% of all cases (1). The remaining cases are represented by variant histology (VH), divided into urothelial and non-urothelial subtypes.

What is the significance of variant histology in urothelial carcinoma?

Patient summary: It is important to recognise histological variants of urothelial carcinoma as they indicate aggressive disease. When compared with patients with pure urothelial carcinoma of the same disease stage, survival does not appear to be significantly worse.

What is variant histology?

Variant histology includes any bladder malignancy other than pure urothelial cancer, such as UC with aberrant differentiation as well as pure non-UC resulting from metaplasia (5).

Is bladder cancer a terminal?

The general 5-year survival rate for people with bladder cancer is 77%. However, survival rates depend on many factors, including the type and stage of bladder cancer that is diagnosed. The 5-year survival rate of people with bladder cancer that has not spread beyond the inner layer of the bladder wall is 96%.

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What is the most aggressive type of bladder cancer?

Muscle invasive bladder cancer is a serious and more advanced stage of bladder cancer. MIBC is when the cancer has grown far into the wall of the bladder (Stages T2 and beyond). For patients with MIBC, the overall prognosis (how the disease may progress) is dependent on stage and treatment.

Is bladder cancer curable if caught early?

Bladder cancer is usually treatable when caught at an early stage but more challenging to address when found later. Recurrence also poses a risk, even with early-stage tumors, so regular surveillance is essential following treatment or surgery.

Do you feel ill with bladder cancer?

Feeling weak or fatigued: You may feel lethargic and extremely tired a lot of the time. Bone pain: If your cancer has spread to the bone, it can cause bone pain or a bone fracture.

Can you have bladder cancer for years and not know it?

Even after reporting the problem to their doctors, blood in the urine may be initially misdiagnosed. It may be seen as a symptom of post-menopausal bleeding, simple cystitis or as a urinary tract infection. As a result, a bladder cancer diagnosis can be overlooked for a year or more.

What is high grade urothelial carcinoma?

High-grade tumors have an aggressive appearance under a microscope and are assumed invasive in the kidney or ureter. In the bladder, a thick bladder muscle (called the detrusor) acts as a barrier to confine invasive cancers but in the kidney and ureter, this muscle does not exist.

What is a cystectomy procedure?

Cystectomy is the surgical removal of all or part of the bladder. It is used to treat bladder cancer that has spread into the bladder wall or to treat cancer that has come back (recurred) following initial treatment. Partial cystectomy is the removal of part of the bladder.

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What is low grade transitional cell carcinoma?

Transitional cell carcinoma can be either low grade or high grade. If it’s low grade, it isn’t likely to spread into deeper layers of your bladder or anywhere else in your body. It’s also less likely to come back after treatment.