How p53 is different from other tumor suppressor gene?


Why the p53 gene is known as a tumour suppressor?

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

What is the p53 gene responsible for?

A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death.

What cancers is p53 associated with?

P53 mutations associated with breast, colorectal, liver, lung, and ovarian cancers. Environ Health Perspect.

How is p53 inactivated?

The p53 protein is such a powerful tumor suppressor that it is inactivated in almost every tumor, through either mutations in the TP53 gene or deregulation of its associated pathways.

What does positive for p53 mean?

Tumors with positive p53 staining showed malignant features compared to negative tumors. Mutation of TP53 gene was observed in 29 (19.6%) tumors with higher age and differentiated type. In positive p53 tumors, two types could be distinguished; aberrant type and scattered type.

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How does p53 get mutated?

P53 is often mutated in solid tumors, in fact, somatic changes involving the gene encoding for p53 (TP53) have been discovered in more than 50% of human malignancies. P53 is a transcription factor able to regulate several intracellular pathways involved in cell survival, DNA-repair, apoptosis and senescence.

Does everyone have p53 gene?

We just have to hope it doesn’t make the mistake in p53! In fact, these kinds of mutations can happen to anyone. Most people that get cancer actually have both of their p53 gene copies mutated, just from random chance.

What happens if both p53 alleles are mutated?

Both inactivation of p53 function and loss of sensitivity to Fas contribute to a malignant phenotype and frequently occur during tumor progression.

Is p53 good or bad?

p53 Germline Mutations and Li–Fraumeni Disease. p53, famously dubbed ‘The Guardian of the Genome’, is arguably the most significant gene for cancer suppression. Somatic loss of function of p53 underpins tumor progression in most epithelial cancers and many others besides.

Which chromosome is p53 located on?

The results show that the human p53 gene is located on chromosome 17. In addition, Southern analysis of hybrids prepared from human cells containing a chromosome 17 translocation allowed regional localization of the human p53 gene to the most distal band on the short arm of this chromosome (17p13).

What happens when p53 is activated?

Upon activation, p53 induces the expression of a variety of gene products, which cause either a prolonged cell-cycle arrest in G1, thereby preventing proliferation of damaged cells, or apoptosis, thereby removing damaged cells from our body.

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What happens when p53 is overexpressed?

Our research showed that was a significant inverse correlation between p53 overexpression and response to chemotherapy and a stronger association between high P53 overexpression (%) and a genetic mutation of p53 (p=0.0001). More than 50% overexpression indicated a strong probability of genetic mutation.

How does p53 detect DNA damage?

After UV-induced DNA damage, activated p53 induces the expression of p48 and XPC, thus increasing the cell’s capacity to locate and target DNA damage for repair.