Is pleomorphic adenoma locally malignant?


Is pleomorphic adenoma benign or malignant?

Pleomorphic adenoma is the most common benign salivary gland neoplasm. In most studies, it represents 45-75% of all salivary gland tumors; the annual incidence is approximately two to three and a half cases per 100,000 population.

Can a pleomorphic adenoma become malignant?

Pleomorphic adenoma is characterized by proliferation of the epithelial-mesenchymal tissue of the salivary gland. Occasionally, a pleomorphic adenoma may undergo malignant transformation resulting in CXPA or carcinosarcoma, respectively. CXPA is an infrequent aggressive malignancy.

Is pleomorphic adenoma premalignant?

Abstract : Atypical pleomorphic adenoma (PA)is a premalignant condition of PA, although its immunoreactivity for HER2/neu, which is a marker for carcinoma (Ca)ex PA, is still unclear.

Should pleomorphic adenoma be removed?

These are very aggressive tumors that are treated by radical parotid surgery followed by post-surgical chemotherapy and radiation therapy. Due to the aggressive nature of this tumor, and poor cure rate, it is advised that benign Pleomorphic adenomas be removed to prevent transformation into this cancer.

How do you treat pleomorphic adenoma?

The treatment of choice for pleomorphic adenomas is surgery, although there is the risk of damaging the nerve and causing a facial paresis. For surgically non resectable tumours, radiation therapy is widely used, which is also an effective adjuvant therapy.

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Can a pleomorphic adenoma come back?

Recurrence within 17 months of initial operation is rare for pleomorphic adenoma, and our patient demonstrates that even a complete parotidectomy may be inadequate in preventing recurrence in certain cases.

What causes carcinoma ex pleomorphic adenoma?

Carcinoma ex pleomorphic adenoma arises from pleomorphic adenoma in a multistep process with genetic alterations of, for example, PLAG1, HMGA2, or mdm2. The prognosis of this group of carcinomas is highly variable, ranging from 30% to 95%, depending on malignant histology and extent of tumor invasion.

What is adenoma carcinoma?

Listen to pronunciation. (A-deh-noh-KAR-sih-NOH-muh) Cancer that begins in glandular (secretory) cells. Glandular cells are found in tissue that lines certain internal organs and makes and releases substances in the body, such as mucus, digestive juices, or other fluids.

What is mixed malignant tumor?

The term “malignant mixed tumor” is usually synonymous with “carcinoma in pleomorphic adenoma,” a secondary carcinoma developing in pre-existing pleomorphic adenoma.

What is acinic cell carcinoma?

Acinic cell carcinoma is an uncommon low-grade malignant tumor of the salivary glands, in which some cells resemble normal acinic cells. 1. Most of these tumors occur in the parotid gland. 1,2. Women are affected more often than men, and the age at occurrence is earlier than in other salivary gland cancers.

Should a parotid tumor be removed?

Treatment Surgery is recommended for almost all parotid gland tumors, whether cancerous or benign. Although most tumors grow slowly and are non-cancerous, they will often continue to grow and occasionally can become cancerous. Treatment of a parotid tumor generally requires removing the parotid gland (parotidectomy).

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