What is a germ cell tumor?
Germ cell tumors are growths of cells that form from reproductive cells. The tumors may be cancerous or not cancerous. Most germ cell tumors occur in the testicles or the ovaries.
What are the two types of germ cell tumors?
There are two types of germ cell tumors that start in the gonads, or reproductive organs: seminomas, which are slower-growing, and nonseminomas, which are faster-growing tumors. These germ cell tumors typically form during puberty.
What is the most common germ cell tumor?
Teratomas are the most common type of germ cell tumor to develop in extragonadal (not in the ovary or testes) areas. Doctors usually treat teratomas with surgery because chemotherapy doesn’t work in a benign tumor.
Can germ cell tumor be cured?
Treatment for malignant tumors includes surgery or chemotherapy. The outlook depends on the stage of the cancer, the tumor’s size and whether it has spread to other parts of your body. Most germ cell tumors are treatable.
What is the survival rate of germ cell tumor?
The 5-year survival rate for teens ages 15 to 19 is 93%. The survival and cure rates also depend on several factors, including the stage of the disease. The cure rate for children with a stage I or stage II germ cell tumor is 90%. The cure rate for a stage III tumor is 87%.
Where are Sertoli cells located?
Sertoli cells are present in the seminiferous tubules of the male gonads, the testes. They were first observed in 1865 by a young Italian physician Enrico Sertoli and named after him. Sertoli cells comprise one of the two types of cells in the germinal epithelium, the other being of spermatogonia lineage.
What is the function of Sertoli cells and Leydig cells?
The Sertoli cells express functional receptors for FSH, whereas the Leydig cells express LH receptors. Thus, these two receptors are mutually exclusive. The LH-stimulated Leydig cell androgen production is essential for the development and maintenance of the male reproductive tract and spermatogenesis .
Is germ cell tumors aggressive?
They form in the testicles and ovaries. It’s often an aggressive cancer that spreads quickly to the lymph nodes and other parts of the body. They’re typically treated with surgery and chemotherapy.
What percentage of germ cell tumors are malignant?
Malignant germ cell tumors of the mediastinum are uncommon, representing only 3 to 10% of tumors originating in the mediastinum. They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms.
Can germ cell tumors spread?
Germ cell tumors can spread (metastasize) to other parts of the body. The most common sites for metastasis are the lungs, liver, lymph nodes, and central nervous system. Rarely, germ cell tumors can spread to the bone, bone marrow, and other organs.