Quick Answer: Does tamoxifen cause cervical cancer?

What cancer does tamoxifen cause?

Because tamoxifen acts like estrogen in the uterus, it can increase your risk of endometrial cancer and uterine sarcoma (cancers of the uterus). It also is linked to a higher risk of endometrial pre-cancers.

Does tamoxifen affect cervix?

Effect of tamoxifen on the cervix

Tamoxifen has estrogen agonist effects on the cervix of postmenopausal women. In one study, 89% of tamoxifen-treated postmenopausal breast cancer patients developed estrogenized cervical smears rather than atrophic smears.

What are the long term side effects of tamoxifen?

Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.

Can tamoxifen cause abnormal Pap smears?

Conclusion: The use of tamoxifen may be associated with benign squamous atypia in cervical smears.

Can I drink green tea while taking tamoxifen?

The combination of tamoxifen with green tea catechins could enhance its action in ER-negative breast cancer. In addition, such a combination could allow a dosage reduction of breast endocrine treatment in ER-positive breast cancer and in breast cancer chemoprophylaxis, leading to an amelioration of the safety profile.

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What is the success rate of tamoxifen?

The study found that patients with 5 years of tamoxifen treatment showed better disease free survival than patients with 10 years of treatment (82% vs 78%, P = . 03), and no statistically significant differences in survival rate were found between these 2 groups (94% vs 91%, P = . 07).

Is it normal to have periods while taking tamoxifen?

Not all women will experience these effects. However, tamoxifen does not induce menopause itself: most women continue having periods, but are cautioned not to become pregnant.

Can you drink alcohol with tamoxifen?

Alcohol can raise the risk of side effects with tamoxifen, some of which can be serious. Alcohol makes it harder for tamoxifen to work properly and should be limited or avoided while you’re taking this medication. Alcohol can raise your risk of developing breast cancer.

How much does tamoxifen reduce the risk of recurrence?

Doctors have long known that five years of tamoxifen reduces recurrence by about half during treatment and by nearly a third over the next five years. Aromatase inhibitors, which work only in postmenopausal women, are even more effective than tamoxifen at reducing recurrence and death from breast cancer.

Why you should not take tamoxifen?

Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.

What foods should not be eaten when taking tamoxifen?

The foods of most concern for women taking tamoxifen are grapefruit and tangerines. Grapefruit is well-known to interfere with numerous medications. Many drug-interaction resources specifically advise that women taking tamoxifen avoid grapefruit.

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Is tamoxifen toxic to the liver?

Tamoxifen is a nonsteroidal antiestrogen that is widely used in the treatment and prevention of breast cancer. Long term tamoxifen therapy has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.