What drugs easily cross the blood-brain barrier?
Recent research has found that drugs of abuse, including cocaine, methamphetamine (METH), morphine, heroin, nicotine, and alcohol, cause BBB dysfunction by altering TJ formation and protein expression (Hawkins and Davis, 2005; Abbott et al., 2006).
Does gemcitabine cross the blood-brain barrier?
Gemcitabine is known to exert a therapeutic effect on brain tumors despite the limited permeability of the blood-brain barrier (BBB).
Does Doxil cross the blood-brain barrier?
We selected doxorubicin as our therapeutic agent. Doxorubicin is currently not used in the treatment of brain tumors because it cannot cross the BBB, but is effective against high-grade gliomas in culture (Stan et al., 1999. (1999). Doxorubicin-induced cell death in highly invasive human gliomas.
Does irinotecan cross the blood-brain barrier?
Irinotecan crosses the blood-brain barrier and, in preclinical investigations, has demonstrated cytotoxic activity against central nervous system tumor xenografts. Its antitumor activity has also been demonstrated against glioblastoma cells with multidrug resistance.
What Cannot cross the blood-brain barrier?
Such substances include lipid-soluble substances (e.g., oxygen, carbon dioxide). Hydrophilic substances, for example, hydron and bicarbonate, are not permitted to pass through cells and across the blood-brain barrier.
What happens when a drug crosses the blood-brain barrier?
The blood–brain barrier (BBB) prevents entry into the brain of most drugs from the blood. The presence of the BBB makes difficult the development of new treatments of brain diseases, or new radiopharmaceuticals for neuroimaging of brain.
Does ifosfamide cross the blood-brain barrier?
IFO and IPM cross the blood–brain barrier and IPM concentrations in the CSF are even higher than in plasma. IFO neurotoxicity can occur following its metabolism to CAA, but the incidence is low, particularly when IFO is administered by continuous intravenous infusion.
Does Taxol cross the blood-brain barrier?
Paclitaxel is a highly lipophylic drug and is likely to be able to pass the intact blood brain barrier on the basis of that chemical property.
Does 5fu cross the blood-brain barrier?
5-FU can cross the brain blood barrier (BBB) by simple diffusion  in animal studies. In humans, 5-FU can diffuse pass BBB and cause encephalopathy  . It has also been found to reduce blood pressure and MDA levels in a hypertensive rat model [24,25]. …
Does doxorubicin cross the BBB?
Doxorubicin (Dox) has got a limited efficacy in the treatment of central nervous system tumors because of its poor penetration through blood-brain barrier mediated by MDR efflux transporters.
Does doxorubicin cause neurotoxicity?
Doxorubicin causes neurotoxicity by facilitating ROS production and mitochondrial membrane depolarization in neurons (19, 22). Doxorubicin increases the MOMP and Bax/Bcl-2 ratio, leading to mitochondrial degeneration and neuronal dysfunction (19, 24).
Does docetaxel cross the blood-brain barrier?
The taxanes paclitaxel (P) and docetaxel (D) do not significantly cross the BBB (brain to plasma exposure of only 1% and 8%, respectively), making them ineffective in treating CNS metastases.
Does cisplatin cross the blood-brain barrier?
Cisplatin doesn’t readily cross the blood-brain barrier. Drug is extensively and irreversibly bound to plasma proteins and tissue proteins.