Why would there be a risk for secondary cancers on treatment with alkylating agents?

Which of the following agents is most likely to cause a secondary malignancy?

Chemotherapy drugs are most strongly associated with causing secondary leukemias and some solid tumors including lung, gastric, and bladder cancers.

Can cancer treatment cause secondary cancer?

Overview. Secondary malignancies are cancers caused by treatment with radiation or chemotherapy. They are unrelated to the first cancer that was treated, and may occur months or even years after initial treatment.

What is the most common secondary cancer?

The most frequently observed solid secondary malignancies are breast cancer, thyroid cancer, and bone/soft tissue sarcomas [6, 12, 33–38].

What is secondary chemotherapy?

by Dr. C.H. Weaver M.D. Medical Editor updated 4/2021. Secondary malignancies are cancers caused by treatment with radiation or chemotherapy. They are unrelated to the first cancer that was treated, and may occur months or even 20 -30 years after initial treatment.

How do secondary cancers form?

Sometimes the new cancer is in the same organ or area of the body as the first cancer. For example, someone who was treated for a certain type of colorectal cancer can get another type of colorectal cancer as a second cancer. Or, a second cancer might develop in another organ or tissue.

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What causes a secondary tumor?

Secondary cancers may occur after chemotherapy, with the most common cancer being leukemia. Drugs which are more likely to cause leukemia include alkylating agents, the platinum drugs, and topoisomerase inhibitors. Some targeted therapy drugs may increase the risk of developing a secondary cancer as well.

What chemo causes a secondary cancer?

Chemotherapy agents that have an increased risk for second cancers include: Alkylating agents (mechlorethamine, chlorambucil, cyclophosphamide, melphalan, lomustine, carmustine, busulfan) Platinum-based drugs (cisplatin, carboplatin)

Which cancer has highest recurrence rate?

Some cancers are difficult to treat and have high rates of recurrence. Glioblastoma, for example, recurs in nearly all patients, despite treatment. The rate of recurrence among patients with ovarian cancer is also high at 85%.

Related Articles.

Cancer Type Recurrence Rate
Glioblastoma2 Nearly 100%

Is secondary cancer the same as metastatic cancer?

A term used to describe cancer that has spread (metastasized) from the place where it first started to another part of the body. Secondary cancers are the same type of cancer as the original (primary) cancer.

What are the chances of getting secondary cancer?

Second cancers are not uncommon. About 1 in every 6 people diagnosed with cancer has had a different type of cancer in the past.

How likely is secondary cancer?

One to three percent of survivors develop a second cancer different from the originally treated cancer. The level of risk is small, and greater numbers of survivors are living longer due to improvements in treatment. However, even thinking about the possibility of having a second cancer can be stressful.

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