Do germ cell tumors come back?

What is the survival rate of germ cell tumor?

The 5-year survival rate for teens ages 15 to 19 is 93%. The survival and cure rates also depend on several factors, including the stage of the disease. The cure rate for children with a stage I or stage II germ cell tumor is 90%. The cure rate for a stage III tumor is 87%.

Do germ cell tumors run in families?

[1] Ovarian germ cell tumors are rare malignancies. Familial clustering of testicular malignancies is well documented in literature. Children or siblings of affected family members are at higher risk for testicular germ cell tumors.

Can Dysgerminoma come back?

Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis.

Is a germ cell tumor a solid tumor?

Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors can usually be distinguished from ovarian cysts, which are much more common, using ultrasound. Germ cell tumors can spread to lymph nodes, lung, liver, and brain.

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Do germ cell tumors grow fast?

There are two types of germ cell tumors that start in the gonads, or reproductive organs: seminomas, which are slower-growing, and nonseminomas, which are faster-growing tumors.

How common is germ cell tumors?

Germ cell tumors are rare. Germ cell tumors account for about 2 to 4 percent of all cancers in children and adolescents younger than age 20. Germ cell tumors can spread (metastasize) to other parts of the body. The most common sites for metastasis are the lungs, liver, lymph nodes, and central nervous system.

How do they treat germ cell tumors?

Treatment options for germ cell tumors may include surgery to remove the tumor, chemotherapy with drugs that kill cancer cells and radiation therapy with powerful energy beams.

Are you born with germ cells?

That’s because as a baby develops before birth, germ cells move into place and become either eggs in the ovaries or sperm in the testicles. Sometimes, a group of germ cells grows in a way that’s not normal. A tumor forms. This usually happens in an ovary or testicle.

Can a germ cell tumor be benign?

Ovarian germ cell tumors grow in the ovaries. The tumors are usually benign (noncancerous), but they can be malignant (cancerous). Treatments include surgery, chemotherapy and radiation.

Are germ cell tumors hereditary?

The cause of germ cell tumors isn’t fully known. Some gene defects passed on from parents to children (inherited) may increase the risk for germ cell tumors. Some genetic syndromes can cause abnormal growth of the male and female reproductive systems.

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How common is dysgerminoma?

The most commonly occurring GCT is the dysgerminoma, which accounts for approximately 2% of all ovarian cancers. Although rare, dysgerminomas are important irrespective of incidence because they most commonly affect women of reproductive age (ie, < 30 y).

Is dysgerminoma curable?

This treatment produces less morbidity than chemotherapy and will cure approximately two-thirds of patients. Chemotherapy should be used for salvage of subsequent relapse. Both radiation and chemotherapy are highly effective treatment modalities for dysgerminoma.

How do you test for germ cell tumors?

In addition to a physical examination, the following tests may be used to diagnose a germ cell tumor:

  1. Biopsy. A biopsy is the removal of a small amount of tissue for examination under a microscope. …
  2. Blood tests. Alpha-fetoprotein (AFP). …
  3. Ultrasound. …
  4. Computed tomography (CT or CAT) scan. …
  5. Magnetic resonance imaging (MRI).

Can adults have germ cell tumors?

Extragonadal germ cell tumors are usually seen in children or young adults and typically arise in midline locations. In adults, the most common sites of primary extragonadal germ cell tumors are, in descending order, the mediastinum, retroperitoneum, and cranium.

Are all germ cell tumors malignant?

Germ cell tumors may be cancerous (malignant) or noncancerous (benign). Although germ cells are usually in the reproductive organs, these cells can sometimes travel to other parts of the body and cause tumors, called extragonadal germ cell tumors.