Frequent question: What is the rationale for using combination chemotherapy?

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What are the advantages of combination therapy for client with cancer?

This approach potentially reduces drug resistance, while simultaneously providing therapeutic anti-cancer benefits, such as reducing tumour growth and metastatic potential, arresting mitotically active cells, reducing cancer stem cell populations, and inducing apoptosis.

What is combination therapy in cancer treatment?

Combination therapy, a treatment modality that combines two or more therapeutic agents, is a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in a characteristically synergistic or an additive manner.

What is the rationale for chemotherapy?

Chemo is considered a systemic treatment because the drugs travels throughout the body, and can kill cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumor.

Why are antineoplastic agents often given in combination?

An antineoplastic drug is one that is used to prevent or treat the growth and spread of tumors or malignant cells; in other words, cancer. Combinations of antineoplastic drugs are usually more effective than single agents alone because each agent has a different way of targeting the way cancer grows.

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What are the side effects of combination therapy?

The most common side-effects of combined chemohormonal therapy were gastro-intestinal (nausea, vomiting, rarely diarrhoea) in 43 patients (57.3%), followed by alopecia in 23 patients (30.6%), myelosuppression in 12 patients (16%), extravasation and thrombophlebitis in 7 patients (9.3%), and mucositis and oral erythema …

Why combination therapy is used in cancer?

The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.

How cancer cells are treated?

Chemotherapy uses drugs to kill cancer cells. Radiation therapy. Radiation therapy uses high-powered energy beams, such as X-rays or protons, to kill cancer cells. Radiation treatment can come from a machine outside your body (external beam radiation), or it can be placed inside your body (brachytherapy).

What is the benefit of combination therapy?

Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.

Why Antibiotics are given in combination?

Combination therapy is mostly practiced because of one or more of the following reasons: Broadening antibacterial spectrum. Use of more than one agent broadens the antibacterial spectrum of the empirical therapy and thus ensures that at least one agent will cover the infecting organism.

How fast does chemo work to shrink tumors?

In general, chemotherapy can take about 3 to 6 months to complete. It may take more or less time, depending on the type of chemo and the stage of your condition. It’s also broken down into cycles, which last 2 to 6 weeks each.

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When is chemo commonly used?

Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body. Many different chemotherapy drugs are available. Chemotherapy drugs can be used alone or in combination to treat a wide variety of cancers.

How many rounds of chemo is normal?

During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.