Is chemo necessary for triple positive breast cancer?

What does it mean to have triple-positive breast cancer?

“Triple-positive” refers to breast tumors that are ER-, PR- and HER2-positive. It means the cancer cells grow in response to estrogen (ER), progesterone (PR) and a growth-promoting protein that’s on the outside of all breast cells known as HER2.

What is the survival rate of triple-positive breast cancer?

According to the National Cancer Institute , these are the 5-year relative survival rates for women who received a breast cancer diagnosis between 2010 and 2016: Localized: 98.9 percent. Regional: 85.7 percent. Distant (or metastatic): 28.1 percent.

What chemo is used for triple-positive breast cancer?

Trastuzumab (Herceptin) and pertuzumab (Perjeta) are the most commonly used drugs used to treat HER2-positive breast cancer. Neratinib (Nerlynx) is another drug that is sometimes given after trastuzumab.

Does grade 3 breast cancer require chemo?

If you have grade 3 breast cancer, you’re more likely to be offered chemotherapy. This is to help destroy any cancer cells that may have spread as a result of the cancer being faster growing. Chemotherapy is less likely for grade 1 and grade 2 cancers.

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What is the treatment for triple-positive breast cancer?

Surgery and chemotherapy are the main triple-positive breast cancer treatments. After surgery, you may need radiation therapy, hormone therapy or targeted therapy against HER2.

Does triple-positive breast cancer come back?

During the study period, recurrences were reported in 11 of 169 patients (6.5%) with triple-positive breast cancer, 29 of 724 patients (4.0%) with the luminal A subtype, and 22 of 206 patients (10.7%) with the HER2-enriched subtype.

Can you live 20 years with metastatic breast cancer?

What is the prognosis? While there is no cure for metastatic breast cancer, there are treatments that slow the cancer, extending the patient’s life while also improving the quality of life, Henry says. Many patients now live 10 years or more after a metastatic diagnosis.

Can you live 20 years after breast cancer?

Since the hazard rate associated with inflammatory breast cancer shows a sharp peak within the first 2 years and a rapid reduction in risk in subsequent years, it is highly likely that the great majority of patients alive 20 years after diagnosis are cured.

What type of breast cancer is most likely to recur?

Among patients who were recurrence-free when they stopped endocrine therapy after five years, the highest risk of recurrence was for those with originally large tumors and cancer that had spread to four or more lymph nodes. These women had a 40 percent risk of a distant cancer recurrence over the next 15 years.

What is the most powerful chemotherapy?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.

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At what stage of cancer is chemotherapy used?

Systemic drug treatments, such as targeted therapy or chemotherapy, are common for stage 4 cancers. Often, a clinical trial may be an option, offering new treatments to help you fight stage 4 cancer.

Is it better to be HER2-positive or negative?

Is HER2-positive breast cancer good or bad? HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast.

Is grade 3 breast cancer bad?

A lower grade number (1) usually means the cancer is slower-growing and less likely to spread. A higher number (3) means a faster-growing cancer that’s more likely to spread.

What kind of breast cancer does not respond to chemo?

The authors conclude that the new findings suggest chemotherapy may be avoided in about 70% of women with HR-positive, HER2-negative, node-negative breast cancer. They say this applies to women who are: older than age 50 and with a recurrence score of 11–25. any age with a recurrence score of 0–10.

How long does chemo last for stage 3 breast cancer?

Adjuvant and neoadjuvant chemo is often given for a total of 3 to 6 months, depending on the drugs used. The length of treatment for advanced breast cancer depends on how well it is working and what side effects you have.