What type of drug is enzalutamide?
Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells.
How long can you survive enzalutamide?
Treatment with Xtandi resulted in a median metastasis-free survival time of 36.6 months versus 14.7 months in the placebo group (95% CI 0.24-0.35; p<0.001). Men treated with Xtandi survived for longer before treatment became ineffective and their prostate cancer started to spread.
What are the side effects of Enzalutamide?
What are the side effects?
- extreme tiredness (fatigue)
- hot flushes.
- high blood pressure.
- feeling nervous.
- problems with memory and concentration.
- dry or itchy skin.
- swelling of the breast area (gynaecomastia)
What is the cost of enzalutamide?
The cost for Xtandi oral capsule 40 mg is around $12,825 for a supply of 120 capsules, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
When is the best time to take enzalutamide?
Enzalutamide is given as a capsule or tablet taken once a day, preferably at the same time each day, with or without food. Take the capsules or tablets whole. Do not break, open, or chew them. If you miss a dose at your regular dose time, take it as soon as you remember that day.
Which is better enzalutamide or abiraterone?
Conclusions: Our results demonstrated that enzalutamide was more efficacious than abiraterone for patients with metastatic castration-resistant prostate cancer, but was associated with a significantly elevated risk of side effects, particularly fatigue.
Can enzalutamide cause hair loss?
Xtandi targets multiple steps in the androgen-receptor–signaling pathway, interfering with molecular pathways that help the cancer grow. What’s more, the drug does not cause side effects commonly associated with chemotherapy, such as nausea and hair loss.
Does enzalutamide make tired?
You may have fatigue (lack of energy) while you’re taking Xtandi. In clinical studies, up to 51% of people taking the drug felt fatigued or tired. Of those taking a placebo (treatment with no active drug), 44% had the same result. If you feel fatigued during Xtandi treatment, talk with your doctor.
How much is Xtandi a month?
The total cost for a one-month supply of Xtandi (120 pills) as listed on in the “Explanation of Benefits” document comes out to $8,839.49, or around $73.66 per pill, $294.64 per day, and $107,617.26 per year. This is the reduced price for medicare patients.
What happens when you stop taking Xtandi?
If your doctor thinks Xtandi has stopped working they will advise you to stop taking it. In about 50 percent of the men whose PSA level starts to rise again while on antiandrogen therapy, stopping treatment will lead to antiandrogen withdrawal syndrome or antiandrogen withdrawal response (AAWR).
Does Xtandi cause confusion?
If you take XTANDI, you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems.
What happens when abiraterone stops working?
If these stop working, the drugs abiraterone (Zytiga), apaleutamide (Erleada), darolutamide (Nubeqa), or enzalutamide (Xtandi) may be effective. The most frequent side effects from hormone therapy include reduced sex drive, impotence, erectile dysfunction, infertility, and bone loss.
What is the difference between enzalutamide and Apalutamide?
In the SPARTAN study, apalutamide reduced the risk for metastasis and death by 72% compared with placebo, and in the PROSPER study, enzalutamide reduced the risk for metastasis by 71% compared with placebo. In addition, in both studies the patients received ongoing androgen-deprivation therapy (ADT).
What is the average cost of Xtandi?
This is a brand name drug and a generic may be available. The average cost for 120 Capsule(s), 40mg each, is $25,033.13. You can buy Xtandi at the discounted price of $12,437.16 by using the WebMDRx coupon, a savings of 50%. Even if this drug is covered by Medicare or your insurance, we recommend you compare prices.
Is Erleada better than Xtandi?
Effectiveness. Erleada and Xtandi have not been directly compared to each other in clinical studies. One study indirectly compared the two drugs as treatment options for people with nmCRPC. The study showed that both drugs may be equally effective in delaying the progression and spread of nmCRPC.