Is a granulosa cell tumor cancer?
Adult-type granulosa cell tumor is a clinically and molecularly unique subtype of ovarian cancer. These tumors originate from the sex cord stromal cells of the ovary and represent 3-5% of all ovarian cancers. The majority of adult-type granulosa cell tumors are diagnosed at an early stage with an indolent prognosis.
Can a granulosa cell tumor be benign?
These can be non cancerous (benign) or cancerous (malignant). Granulosa cell tumours are the most common type. Treatment depends on several factors including your age, the type of tumour, and how advanced it is (the stage). Most women are diagnosed at an early stage and treatment usually works well.
Can granulosa cell tumors spread?
GCT of the ovary is most often diagnosed at stage 1. That means the tumor cells have not spread beyond the ovary.
Is granulosa cell tumor benign or malignant?
GCTs are thought to be tumors of low malignant potential. Most of these tumors follow a benign course, with only a small percentage showing aggressive behavior, perhaps due to early stage at diagnosis. Metastatic disease can involve any organ system, although tumor growth usually is confined to the abdomen and pelvis.
Can you be fully cured of ovarian cancer?
Approximately 20% of women with advanced-stage ovarian cancer survive beyond 12 years after treatment and are effectively cured. Initial therapy for ovarian cancer comprises surgery and chemotherapy, and is given with the goal of eradicating as many cancer cells as possible.
Is granulosa cell tumor cancer hereditary?
Adult granulosa cell tumors can occur in familial clusters and could potentially be hereditary.
Does size of ovarian tumor matter?
When it comes to ovarian cancer, size doesn’t necessarily matter: Smaller tumors are just as likely to be malignant. Unfortunately, symptoms of ovarian cancer are vague, causing women to delay seeking care.
Do ovarian tumors grow fast?
Ovarian cancer grows quickly and can progress from early stages to advanced within a year. With the most common form, malignant epithelial carcinoma, the cancer cells can grow out of control quickly and spread in weeks or months.
What is the tumor marker for granulosa cell tumor?
Lappöhn et al showed that inhibin can be used as a marker of granulosa cell tumors (GCT). Inhibin ia s glycoprotein specifically produced by ovarian granulosa cells.
What is the function of granulosa cells?
The granulosa cell (GC) is a critical somatic component of the ovary. It is essential for follicle development by supporting the developing oocyte, proliferating and producing sex steroids and disparate growth factors.
What does high inhibin B mean?
Elevated levels of inhibin A and/or inhibin B may be present in the blood of a woman with a rare type of ovarian tumor called a granulosa cell tumor (the most common type of sex-cord stromal tumor). Blood levels of these hormones may also be elevated in some women with mucinous epithelial tumors.
What is a yolk sac tumor?
Listen to pronunciation. (yok sak TOO-mer) A rare type of cancer that begins in germ cells (cells that form sperm or eggs). Yolk sac tumors occur most often in the ovary or testicle, but they may also occur in other areas of the body, such as the chest, abdomen, or brain.
How is granulosa cell tumor diagnosed?
These visits should include updating the medical history, a pelvic examination, and possibly blood testing to look for chemicals produced by cancer cells ( tumor markers ). If there are any suspicious findings during these visits, an imaging test such as a CT scan may be done.
Is fibroma malignant?
They can grow in all organs, arising from mesenchyme tissue. The term “fibroblastic” or “fibromatous” is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors.