Question: What gene is responsible for melanoma?

What is the gene that causes melanoma?

People who carry a mutation on a gene known as CDKN2A have a higher risk of developing melanoma, cancer of the pancreas, or a tumor in the central nervous system. A mutation on the gene called BAP1 means a higher risk of getting melanoma, melanoma of the eye, or cancers like mesothelioma and kidney cancer.

What is the most common mutation in malignant melanoma?

CDKN2A gene

Mutations in this gene are the most common cause of inherited melanoma.

Is melanoma recessive or dominant?

In fair-complexioned individuals worldwide, the majority of melanoma cases are related to environmental factors such as excessive ultraviolet radiation (sun exposure). However, about 5-10% of melanoma cases are inherited in an autosomal dominant fashion.

Does melanoma occur only on exposed skin?

Melanoma signs and symptoms

In both men and women, melanoma can occur on skin that hasn’t been exposed to the sun. Melanoma can affect people of any skin tone. In people with darker skin tones, melanoma tends to occur on the palms or soles, or under the fingernails or toenails.

Can you have melanoma for years and not know?

How long can you have melanoma and not know it? It depends on the type of melanoma. For example, nodular melanoma grows rapidly over a matter of weeks, while a radial melanoma can slowly spread over the span of a decade. Like a cavity, a melanoma may grow for years before producing any significant symptoms.

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How do you know if melanoma has spread?

For people with more-advanced melanomas, doctors may recommend imaging tests to look for signs that the cancer has spread to other areas of the body. Imaging tests may include X-rays, CT scans and positron emission tomography (PET) scans.

What cell mutates cause melanoma?

The most common change in melanoma cells is a mutation in the BRAF oncogene, which is found in about half of all melanomas. Other genes that can be affected in melanoma include NRAS, CDKN2A, and NF1. (Usually only one of these genes is affected.)

Is melanoma linked to other cancers?

People who’ve had melanoma can still get other cancers. In fact, melanoma survivors are at higher risk for getting some other types of cancer: Another skin cancer, including melanoma (this is different from the first cancer coming back) Salivary gland cancer.

What does melanoma on the leg look like?

Border that is irregular: The edges are often ragged, notched, or blurred in outline. The pigment may spread into the surrounding skin. Color that is uneven: Shades of black, brown, and tan may be present. Areas of white, gray, red, pink, or blue may also be seen.

Can melanoma be benign?

Melanoma, benign: A benign growth of the melanocytes that is not cancerous.