Quick Answer: Why telomerase inhibitors are used as anti cancer agents?


How does telomerase prevent cancer?

The DNA in telomeres shortens when cells divide, eventually halting cell division when the telomere reserve is depleted.” New results from de Lange’s lab provide the first evidence that telomere shortening helps prevent cancer in humans, likely because of its power to curtail cell division.

What does a telomerase inhibitor do?

Inhibition of telomerase prevents the maintenance of telomere length in telomerase-positive cells. As a result, telomerase may shorten, leading to eventual replicative senescence or apoptosis.

Does telomerase help cancer?

Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem-like cells.

What is the rationale for developing anti cancer agents that inhibit telomerase?

6). Therefore, the rationale for anti-telomerase immunotherapy is to sensitize the immune system to tumor cells expressing hTERT peptides to activate and generate hTERT-specific CD8+ cells to produce enhanced anti-tumor effects.

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Is telomerase more active in cancer cells?

For this reason, some have called telomerase the “immortality enzyme.” Nevertheless, the telomeres in cancer cells are generally shorter than telomeres in normal cells. Since telomerase is active in cancer cells but not normal cells, it is seen as a promising target for cancer therapy.

How is telomerase linked to cancer cells?

Telomerase activity is closely related to the life stages of the body. The enzyme is active during embryonic development. Cancer cells are characterized by high telomerase activity, which enables cells to divide indefinitely. Telomerase is active in 85–95% of cancers (3,4).

How do you stop telomerase?

Dietary restriction, appropriate diet (high fiber, plenty of antioxidants, lean/low protein, adding soy protein to diet), and regular exercise can potentially reduce the rate of telomere shortening, disease risk, and pace of aging.

How can telomerase activity be reduced?

The RNA component of telomerase has also been a popular and effective target for inhibiting telomerase activity in cancer cells. As in the case for TERT transcript knockdown, antisense oligonucleotides against the human TR template can be employed to reduce or eliminate telomerase activity as described in Chapter 9.

Is telomerase good or bad?

Too much telomerase can help confer immortality onto cancer cells and actually increase the likelihood of cancer, whereas too little telomerase can also increase cancer by depleting the healthy regenerative potential of the body.

Why do telomeres not shorten in cancer cells?

Cancer cells maintain the telomere length for unlimited growth by telomerase reactivation or a recombination-based mechanism. Recent genome-wide analyses have unveiled genetic and epigenetic alterations of the telomere maintenance machinery in cancer.

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How can an active telomerase lead to cancer?

If a genetic mishap inadvertently turns telomerase production on, it can cause abnormal cells to multiply and form tumors. It is believed that as life expectancy rates continue to grow, the chances of this occur will not only become greater but eventually become inevitable.

Can telomerase reverse aging?

An enzyme called telomerase can slow, stop or perhaps even reverse the telomere shortening that happens as we age. The amount of telomerase in our bodies declines as we age.

What is the role of telomerase in cells?

Telomerase is a cellular reverse transcriptase that helps to provide genomic stability in highly proliferative normal, immortal, and tumor cells by maintaining the integrity of the chromosome ends, the telomeres. The activity of telomerase is associated with the majority of malignant human cancers.

Do humans have telomerase?

Telomerase has been detected in human cancer cells and is found to be 10-20 times more active than in normal body cells. This provides a selective growth advantage to many types of tumors.