What is the most likely reason for a heterogeneous genetic makeup of a tumor that arises from a single cell?


What does heterogeneous mean in cancer?

Tumour heterogeneity describes differences between tumours of the same type in different patients, and between cancer cells within a tumour. Both can lead to different responses to therapy.

Why is it important to a cancer’s survival to have a heterogeneous cell environment?

Thus, clonally heterogeneous tumors can generate a larger variety of genetic variants to be tested by selection. In other words, genetically diverse tumors can explore larger areas of adaptive landscape, increasing the probability of clones reaching fitness peaks (Fig.

How does heterogeneity develop in Tumours?

In summary, tumor heterogeneity is undoubtedly due, at least in part, to the stability of multiple genomic clonal populations within a neoplasm. These arise from divergent evolution of the originating cells’ progeny and may be sustained by geographical isolation within the tumor and cooperation between clones.

What does heterogeneous mean medically?

Heterogeneous refers to a structure with dissimilar components or elements, appearing irregular or variegated. For example, a dermoid cyst has heterogeneous attenuation on CT. It is the antonym for homogeneous, meaning a structure with similar components.

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What does heterogeneous appearance mean?

Heterogeneous is a word pathologists use to describe tissue that looks very different from one area of the tissue to the next. Differences in colour, shape, and size can make a tissue look heterogeneous. Heterogeneous can be used to describe the way the tissue looks with or without a microscope.

What is a problem associated with tumor heterogeneity?

Tumor heterogeneity presents resistant clones that are not responsive to matching targeted therapy. Thus, targeting only one abnormality is not sufficient to be lethal for most, if not all, cancer cells [Engelman et al.

Why are tumors heterogeneous?

Phenotypic and functional heterogeneity arise among cancer cells within the same tumor as a consequence of genetic change, environmental differences, and reversible changes in cellular properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny.

What is called heterogeneous?

: consisting of dissimilar or diverse ingredients or constituents : mixed an ethnically heterogeneous population. Other Words from heterogeneous Synonyms & Antonyms More Example Sentences Learn More About heterogeneous.

Can a heterogeneous mass be benign?

Soft tissue tumors are a heterogeneous group of benign and malignant lesions that develop from various nonepithelial, extraskeletal elements, including adipose tissue, smooth and skeletal muscle, tendon, cartilage, fibrous tissue, blood vessels, and lymphatic structures.

What is a heterogeneous condition?

A heterogeneous medical condition or heterogeneous disease is a medical term referring to a medical condition with several etiologies (root causes), such as hepatitis or diabetes.

Are tumors clonal?

A neoplasm that has a clonal origin begins, by definition, in one cell (e.g. in an A cell), and thus all cells in that tumor will have one type (A) as descendants of the one A progenitor cell. If, in contrast, a tumor is found to contain neoplastic cells of both A and B types, it must have had a multicellular origin.

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Can you tell if a mass is cancerous without a biopsy?

Normal cells will look uniform, and cancer cells will appear disorganized and irregular. Most of the time, a biopsy is needed to know for sure if you have cancer. It’s considered the only definitive way to make a diagnosis for most cancers.

Does a mass mean cancer?

In medicine, a lump in the body. It may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction. A mass may be benign (not cancer) or malignant (cancer).

How do you know if a mass is cancerous?

Bumps that are cancerous are typically large, hard, painless to the touch and appear spontaneously. The mass will grow in size steadily over the weeks and months. Cancerous lumps that can be felt from the outside of your body can appear in the breast, testicle, or neck, but also in the arms and legs.