Which lymphoma is caused by EBV and what is its pathogenesis?

Introduction: Epstein–Barr virus infection, virus-induced lymphoproliferative diseases and the virus-associated lymphomas

What lymphoma is caused by EBV?

The Epstein-Barr virus (EBV) is the virus that causes mononucleosis, also known as “mono,” and it is associated with some types of NHL. These include Burkitt lymphoma, lymphomas occurring after an organ transplant, and, rarely, other lymphomas in people who are otherwise healthy.

What is the pathogenesis of EBV?

Epstein-Barr virus (EBV) maintains a lifelong infection. According to the germinal center model (GCM), latently infected B cells transit the germinal center (GC) to become resting memory cells. Here, the virus resides quiescently, occasionally reactivating to infect new B cells, completing the cycle of infection.

Which Hodgkin lymphoma is associated with EBV?

EBV or human herpes virus 4 is closely associated with the GC B cell malignancies Burkitt lymphoma, post transplantation lymphomas and HL.

What type of cancer is caused by Epstein-Barr?

EBV infection increases a person’s risk of getting nasopharyngeal cancer (cancer of the area in the back of the nose) and certain types of fast-growing lymphomas such as Burkitt lymphoma. It may also be linked to Hodgkin lymphoma and some cases of stomach cancer.

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What kills Epstein-Barr virus?

Ascorbic Acid Kills Epstein-Barr Virus (EBV) Positive Burkitt Lymphoma Cells and EBV Transformed B-Cells in Vitro, but not in Vivo. Amber N.

What are the symptoms of reactivated EBV?

What Are the Symptoms of EBV Reactivation?

  • Swollen tonsils.
  • Extreme fatigue.
  • Rash.
  • Sore throat.
  • Headache.
  • Enlarged spleen (splenomegaly)
  • Swollen liver.
  • Swollen lymph nodes.

Why is Heterophile antibody produced during EBV infection?

The heterophile antibody is an immunoglobulin M (IgM) antibody produced by infected B lymphocytes. It is not directed against Epstein-Barr virus (EBV) or EBV-infected cells, but it is a result of the infection and the subsequent transformation of the B cell to a plasmacytoid state.

Which country world region has the highest incidence of Epstein-Barr virus?

Analysis of EBV-attributed malignancies in 21 world regions revealed that the highest mortality was in East Asia (Figure 1). In fact 47% of all EBV-attributed malignancies occurred in this region.

What does positive Epstein-Barr test mean?

If someone is positive for VCA-IgM antibodies, then it is likely that the person has an EBV infection and it may be early in the course of the illness. If the individual also has symptoms associated with mono, then it is most likely that the person will be diagnosed with mono, even if the mono test was negative.

What is EBV positive lymphoma?

EBV-related lymphomas are a heterogeneous group of hematologic malignancies but share the feature of harboring latent EBV within tumor cells. Certain lymphomas, such as endemic BL or HIV-associated primary central nervous system lymphoma, are EBV-positive in virtually 100% of cases.

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Is EBV lymphoma curable?

In patients older than 45 years, the 5-year disease free survival was 37% in EBV+ cases vs. 74% in EBV cases (p = 0.02). In patients younger than 45 years, the 5-year disease free survival was 50% in EBV+ cases vs. 67% in EBV cases (p = 0.17).

What are the long term effects of Epstein-Barr?

More serious complications may include anemia , nerve damage, liver failure, and/or interstitial pneumonia. Symptoms may be constant or come and go, and tend to get worse over time. CAEBV occurs when the virus remains ‘active’ and the symptoms of an EBV infection do not go away.

Is Epstein-Barr related to HPV?

Two DNA viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), are associated with 38% of all virus-associated cancers. The probability of one patient infected with these two distinct types of viruses is increasing.