Which paraneoplastic syndrome is associated with lymphoma?

General overview of PNSs in lymphomas

What cancers cause paraneoplastic syndrome?

The types of cancer most likely to cause paraneoplastic syndromes are:

  • Breast.
  • Gastric (stomach)
  • Leukemia.
  • Lymphoma.
  • Lung, especially small cell lung cancer.
  • Ovarian.
  • Pancreatic.
  • Renal (kidney)

What is the most common paraneoplastic syndrome?

Endocrine syndromes, particularly syndrome of inappropriate ADH secretion (SIADH) and humoral hypercalcemia of malignancy (HHM) are the most common paraneoplastic syndromes seen in lung cancer and are related to the histologic type of cancer (1).

Which is an example of a paraneoplastic syndrome?

Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.

What cancers are related to lymphoma?

People who have had non-Hodgkin lymphoma (NHL) can get any type of second cancer, but they have an increased risk of certain cancers, including: Melanoma skin cancer. Lung cancer. Kidney cancer.

How rare is paraneoplastic syndrome?

Paraneoplastic neurological syndromes (PNS) can be defined as remote effects of cancer that are not caused by the tumor and its metastasis, or by infection, ischemia or metabolic disruptions. PNS are rare, affecting less than 1/10,000 patients with cancer.

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Who treats paraneoplastic syndrome?

Mayo Clinic doctors trained in nervous system conditions (neurologists), cancer (oncologists) and other specialties have experience evaluating and treating people with paraneoplastic syndromes of the nervous system.

What is Stauffer syndrome?

Stauffer’s syndrome is a rare paraneoplastic manifestation of renal cell carcinoma (RCC) that is characterized by elevated alkaline phosphatase, erythrocyte sedimentation rate, α-2-globulin, and γ-glutamyl transferase, thrombocytosis, prolongation of prothrombin time, and hepatosplenomegaly, in the absence of hepatic …

What are paraneoplastic symptoms?


  • Difficulty walking.
  • Difficulty maintaining balance.
  • Loss of muscle coordination.
  • Loss of muscle tone or weakness.
  • Loss of fine motor skills, such as picking up objects.
  • Difficulty swallowing.
  • Slurred speech or stuttering.
  • Memory loss and other thinking (cognitive) impairment.

Which lung cancers cause paraneoplastic syndrome?

Most paraneoplastic syndromes are caused by small cell lung cancer (SCLC). However many paraneoplastic syndromes also occur in non–small cell lung cancer (NSCLC) patients. Some examples include: Hypercalcemia due to parathyroid-like hormone production occurs most commonly in patients with SCCs.

Is paraneoplastic syndrome progressive?

The symptoms of paraneoplastic cerebellar degeneration can be rapidly progressive and very debilitating. They can also precede the diagnosis of the underlying malignancy. Thus, prompt recognition and treatment of this disease are crucial to the prevention of significant disability.

What is paraneoplastic neuropathy?

A neuropathy is defined as paraneoplastic when none of the above causes are detected or when cancer related immunological mechanisms are involved. At least 15% of patients with cancer develop a paraneoplastic sensorimotor neuropathy, which is usually mild and develops during the terminal stage of the disease.

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What does a paraneoplastic panel test for?

You may have blood drawn for a number of laboratory tests, including tests to identify antibodies commonly associated with paraneoplastic syndromes. Other tests may attempt to identify an infection, a hormone disorder or a disorder in processing nutrients (metabolic disorder) that could be causing your symptoms.