Why is chronic inflammation regarded as pro tumor factor in some cases?


Why is chronic inflammation a risk factor for cancer?

Chronic inflammation may be caused by infections that don’t go away, abnormal immune reactions to normal tissues, or conditions such as obesity. Over time, chronic inflammation can cause DNA damage and lead to cancer.

Why is inflammation good for cancer?

Other times, the inflammatory process produces molecules called cytokines, which stimulate the growth of blood vessels that bring oxygen and nutrients to the tumor. The process also may generate molecules called free radicals that further damage the DNA.

What causes Pro tumor inflammation?

Furthermore, tumor-extrinsic inflammation is known to be triggered by various factors, including autoimmune diseases, bacterial and viral infections, obesity, smoking, asbestos exposure, and excessive alcohol consumption, all of which have been reported to increase cancer risk and accelerate malignant progression.

How does inflammation promote tumor growth?

(B) Inflammatory entities, such as cytokines and growth factors, release by immune cells within the TME can have a direct effect on pre-malignant and cancer cells by increasing their proliferation and resistance to cell death and stresses, thereby directly promoting tumor growth and progression.

What is the relationship between chronic inflammation and cancer?

But sometimes inflammation begins for other reasons and it doesn’t stop. This type of inflammation is called chronic inflammation. Over time it can cause damage to cell DNA and affect the way cells grow and divide. That could lead to the growth of tumors and cancer.

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Do blood tests show cancer markers?

With the exception of blood cancers, blood tests generally can’t absolutely tell whether you have cancer or some other noncancerous condition, but they can give your doctor clues about what’s going on inside your body.

How does chronic inflammation cause DNA damage?

Under inflammatory conditions, inflammatory and epithelial cells release reactive oxygen (ROS) and nitrogen species (RNS), which are capable of causing DNA damage, including the formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-nitroguanine.

How does inflammation damage DNA?

Inflammation results in DNA damage in part because the immune system’s host-defense response includes production of reactive oxygen and nitrogen species to attack pathogens, but these chemicals can also damage the body’s own biomolecules, including DNA.

Does inflammation go away on its own?

Acute inflammation should go away within a few days, unless it’s left untreated. If you’re experiencing any signs of long-term inflammation, make an appointment with your doctor. They can run some tests and review your symptoms to see if you need treatment for any underlying conditions.